MBC BioLabs
953 Indiana St., San Francisco, CA 94107
OUR DISCOVERY
targeting chromatin networks
While billions of dollars have been poured into drugging chromatin regulatory factors, the toxicity and limited efficacy of previous approaches limits potential and promise. TippingPoint’s platform solves this core problem by taking a completely new approach to drugging chromatin - targeting the unstructured regions in chromatin proteins by exploiting unique inter-molecular interfaces only found in disease driving chromatin states. This approach should increase specificity, reduce toxicity and be less susceptible to drug resistance.
OUR MISSION & VISION
TippingPoint Biosciences' mission is to treat diseases caused by dysfunctional genome chromatin packaging that are difficult to target using conventional approaches.
Chromatin structure dictates cell function and identity.
OUR SOLUTION
Team & advisory
Dr. Laura Hsieh is a former UCSF and American Cancer Society postdoctoral fellow in Dr.Narlikar’s lab and original inventor of the platform
Dr. Geeta Narlikar is Professor and Chair at the Biochemistry and Biophysics Department in UCSF and member of the US National Academy of Sci
Dr. Muryam Gourdet obtained her PhD from the TETRAD program at UCSF.
Experienced drug discovery Scientist| Cancer biologist
Dr. Donna Huryn is a Chemistry Professor at University of Pennsylvania, American Chemical Society Fellow and former medicinal chemist at Hof
Dr. Li was most recently the Senior Vice President and Head or Translational Medicine at RazyeBio, the former Senior Vice President of Trans
Dr. David Raleigh is an Assistant Professor of Radiation Oncology at UCSF and Brain Tumor Center Preclinical Therapeutics Core Director.
Dr. Michelle Monje is a HHMI Professor of Neurology and Neuro-Oncologist at Stanford University and MacArthur Fellow.
Dr. Mike Keiser was a Professor of Pharmaceutical Chemistry at UCSF and co-founder of a stealth start-up. His expertise is in developing ML
Dr. Paula Ragan is the, Founder, CEO & President of X4 Pharmaceuticals. She was also a former CBO consultant at Lysosomal Therapeutics a
Dr. Ralph Lin is currently at Avidity Biosciences. He has held multiple leadership roles at various biotech companies including Arena Pharma
Dr. Danica Fujimori is a Professor in the Department of Pharmacology at UCSF and co-founder of a stealth start-up.
Dr. Laura Hsieh is a former UCSF and American Cancer Society postdoctoral fellow in Dr.Narlikar’s lab and original inventor of the platform
Dr. Geeta Narlikar is Professor and Chair at the Biochemistry and Biophysics Department in UCSF and member of the US National Academy of Sci
Dr. Muryam Gourdet obtained her PhD from the TETRAD program at UCSF.
Experienced drug discovery Scientist| Cancer biologist
Dr. Donna Huryn is a Chemistry Professor at University of Pennsylvania, American Chemical Society Fellow and former medicinal chemist at Hof
Dr. Li was most recently the Senior Vice President and Head or Translational Medicine at RazyeBio, the former Senior Vice President of Trans
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Open positions
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NEWS & PRESS RELEASES
Stay informed to empower yourself with the latest knowledge and insights.
October 30, 2024
Pilot & first-year Platinum Program has provided eight companies pre-seed funding totaling $3.5 million, lab space, and mentorship and is now offering drug discovery and corporate advisory services from new sponsors Alloy Therapeutics, Goodwin, and van den Boom & Associates
September 4, 2024
TippingPoint Biosciences, a therapeutic company focused on innovative drug discovery targeting the aberrant DNA in cancer cells, today announced pre-seed investment from the Pediatric Brain Tumor Foundation, Sontag Foundation, Yuvaan Tiwari Foundation, and BrightEdge, the impact investment and venture capital arm of the American Cancer Society.
December 12, 2023
Astellas received more than 25 applications for the prize. After careful consideration and a competitive pitch process, both companies were chosen for strength of the innovation in their approach, the therapeutic potential of their research and expandability of their technological platforms.
November 9, 2023
Within each of the trillions of cells in our bodies, more than six feet of DNA is carefully packaged, encoding instructions for the biological processes we need to live. The secret to that precise packaging, which allows so much DNA to compress into the tiny space of a cell’s nucleus, lies in the power of the nucleosome.
October 17, 2023
More than 30 startups — including 18 from the Bay Area — pitched to investors at an event leading up to the Biotechnology Innovation Organization's Investor Forum on Tuesday and Wednesday.
September 15, 2023
We talked with the founder of TippingPoint Biosciences — Laura Hsieh, CEO — in the basement of IndieBio last week after her company had just been voted “Killer of the Week” by her peers in Batch 14. Each week at IndieBio, the companies in our batch compete based on their top accomplishments just in the previous week as they learn to move at venture speed. Top companies are nominated by the IndieBio SF team, but the winner is ultimately chosen by a voting of their peers within the batch.
January 7, 2023
A wide number of cancers exhibit misregulated genome packaging at the chromatin level. If chromatin that should be tightly condensed, becomes loosely packed (or vice-versa), the normal brakes on cell growth aren’t operant, leading to uncontrolled cell growth. Being able to regulate and control the chromatin state has been a high-value target for oncology.
December 12, 2023
Astellas received more than 25 applications for the prize. After careful consideration and a competitive pitch process, both companies were chosen for strength of the innovation in their approach, the therapeutic potential of their research and expandability of their technological platforms.
October 17, 2023
More than 30 startups — including 18 from the Bay Area — pitched to investors at an event leading up to the Biotechnology Innovation Organization's Investor Forum on Tuesday and Wednesday.
November 9, 2023
Within each of the trillions of cells in our bodies, more than six feet of DNA is carefully packaged, encoding instructions for the biological processes we need to live. The secret to that precise packaging, which allows so much DNA to compress into the tiny space of a cell’s nucleus, lies in the power of the nucleosome.
September 15, 2023
We talked with the founder of TippingPoint Biosciences — Laura Hsieh, CEO — in the basement of IndieBio last week after her company had just been voted “Killer of the Week” by her peers in Batch 14. Each week at IndieBio, the companies in our batch compete based on their top accomplishments just in the previous week as they learn to move at venture speed. Top companies are nominated by the IndieBio SF team, but the winner is ultimately chosen by a voting of their peers within the batch.
January 7, 2023
A wide number of cancers exhibit misregulated genome packaging at the chromatin level. If chromatin that should be tightly condensed, becomes loosely packed (or vice-versa), the normal brakes on cell growth aren’t operant, leading to uncontrolled cell growth. Being able to regulate and control the chromatin state has been a high-value target for oncology.
If you are interested in learning more about our revolutionary technology, please contact us at:
hello@tippingpointbiosciences.com
